Developmental effects of oxytocin on stress
response: single versus repeated exposure
by
Kramer KM, Cushing BS, Carter CS.
The Brain-Body Center, Department of Psychiatry,
University of Illinois at Chicago,
Chicago, IL 60612, USA.
kkramer@psych.uic.edu
Physiol Behav. 2003 Sep;79(4-5):775-82.
ABSTRACTBoth exogenous and endogenous oxytocin (OT) are associated with an attenuated stress response. Increased levels of OT in the early postnatal period have been shown to affect behavior and physiology in rodents, and these effects last into adulthood, suggesting an organizational role for OT during development. We investigated the effects of neonatal exposure to OT on the development of the stress response in male and female prairie voles (Microtus ochrogaster). OT or an OT antagonist (OTA) was administered either on postnatal day 1 (single, D1) or days 1-7 (repeated, D1-7) and then on day 8 the response to social isolation was assessed by quantifying ultrasonic vocalizations (USVs) and measuring plasma corticosterone (CORT). Treatment effects were observed only in females. A single treatment with OTA was associated with a decrease in vocalizations, while repeated treatment produced an increase in vocalizations. A single treatment with either saline or OTA increased basal CORT. The results suggest that endogenous OT may be involved in the development of the stress response in females.Stress
Oxytocin
Monogamy
Vasopressin
Cuddle hormone
The power of love
Oxytocin and voles
Oxytocin and drugs
Oxytocin and women
Oxytocin and estradiol
Hyper-reactive HPA rats
The evolution of emotion
Oxytocin and the randy rat
Oxytocin and social interaction
Oxytocin, addiction and the science of loveand further reading
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